BAKER BROS. ADVISORS LP Holdings

BAKER BROS. ADVISORS LP is an investment fund managing more than 15.27B US dollars. The largest holdings include Seagen, Incyte and BeiGene, Ltd.. In Q3 2022 the fund bought assets of total value of 26.45M US dollars and sold assets of total value of 577.82M US dollars.

$15.26B

portfolio value

-11.67%

quarter

-33.99%

1 year

+3.50%

3 years

+7.76%

5 years

BAKER BROS. ADVISORS LP portfolio changes

Portfolio changes (number of shares)
Period	Buy	Sel
Q1 2016	-931104000	100827000
Q2 2016	485687000	139611000
Q3 2016	1216699000	6836000
Q4 2016	358469000	905792000
Q1 2017	2847779000	119696000
Q2 2017	-326653000	117195000
Q3 2017	236192000	94102000
Q4 2017	-141523000	266218000
Q1 2018	608544000	137833000
Q2 2018	1936449000	185103000
Q3 2018	1184199000	196528000
Q4 2018	-120986000	596525000
Q1 2019	2756131000	55685000
Q2 2019	277921000	1097040000
Q3 2019	354549000	127327000
Q4 2019	1793993000	94077000
Q1 2020	-750810000	262905000
Q2 2020	2028222000	2159972000
Q3 2020	11175424000	8254507000
Q4 2020	2179880000	954380000
Q1 2021	-2707646000	912610000
Q2 2021	1115185000	1032953000
Q3 2021	157330000	316570000
Q4 2021	539585000	914835000
Q1 2022	-1108837000	89886000
Q2 2022	-496008000	173025000
Q3 2022	26446000	577821000

BAKER BROS. ADVISORS LP 13F holdings

Stock	Position type	Portfolio share	Portfolio value	Avg. open price	Current price	P/L	Last change
Biotechnology Seagen Inc. Portfolio share: 42.04% Portfolio value: 6.41B Avg. open price: $49.18 Current price: $121.22 P/L: +146.46% Bought +0.04% shares Q1 2022	share	42.04%	6.41B	$49.18	$121.22	+146.46%	Bought +0.04% shares Q1 2022
Biotechnology Incyte Corporation Portfolio share: 15.78% Portfolio value: 2.40B Avg. open price: $95.92 Current price: $84.08 P/L: -12.34% Bought 0.00% shares Q3 2022	share	15.78%	2.40B	$95.92	$84.08	-12.34%	Bought 0.00% shares Q3 2022
Biotechnology BeiGene, Ltd. Portfolio share: 10.30% Portfolio value: 1.57B Avg. open price: $135.53 Current price: $188.71 P/L: +39.24% Sold -12.27% shares Q4 2020	share	10.30%	1.57B	$135.53	$188.71	+39.24%	Sold -12.27% shares Q4 2020
Biotechnology ACADIA Pharmaceuticals Inc. Portfolio share: 4.49% Portfolio value: 685.86M Avg. open price: $26.38 Current price: $15.24 P/L: -42.23% Bought +0.03% shares Q2 2022	share	4.49%	685.86M	$26.38	$15.24	-42.23%	Bought +0.03% shares Q2 2022
Biotechnology BioMarin Pharmaceutical Inc. Portfolio share: 4.23% Portfolio value: 645.98M Avg. open price: $93.64 Current price: $103.53 P/L: +10.56% Bought +0.41% shares Q3 2021	share	4.23%	645.98M	$93.64	$103.53	+10.56%	Bought +0.41% shares Q3 2021
Biotechnology Ascendis Pharma A/S Portfolio share: 3.28% Portfolio value: 501.08M Avg. open price: $66.26 Current price: $119.41 P/L: +80.20% Bought +6.85% shares Q2 2022	share	3.28%	501.08M	$66.26	$119.41	+80.20%	Bought +6.85% shares Q2 2022
Biotechnology Global Blood Therapeutics, Inc. Portfolio share: 1.66% Portfolio value: 254.18M Avg. open price: $45.82 Current price: $68.49 P/L: +49.47% Bought +12.60% shares Q2 2022	share	1.66%	254.18M	$45.82	$68.49	+49.47%	Bought +12.60% shares Q2 2022
Biotechnology BioCryst Pharmaceuticals, Inc. Portfolio share: 1.05% Portfolio value: 160.15M Avg. open price: $4.86 Current price: $11.58 P/L: +138.26% Bought +0.12% shares Q1 2021	share	1.05%	160.15M	$4.86	$11.58	+138.26%	Bought +0.12% shares Q1 2021
Biotechnology Rhythm Pharmaceuticals, Inc. Portfolio share: 0.97% Portfolio value: 148.53M Avg. open price: $15.14 Current price: $27.14 P/L: +79.23% Bought +46.97% shares Q3 2022	share	0.97%	148.53M	$15.14	$27.14	+79.23%	Bought +46.97% shares Q3 2022
Biotechnology Kodiak Sciences Inc. Portfolio share: 0.88% Portfolio value: 133.98M Avg. open price: $48.92 Current price: $7.26 P/L: -85.16% Bought +8.66% shares Q2 2022	share	0.88%	133.98M	$48.92	$7.26	-85.16%	Bought +8.66% shares Q2 2022
Biotechnology Immunocore Holdings plc Portfolio share: 0.77% Portfolio value: 118.32M Avg. open price: $37.31 Current price: $58.07 P/L: +55.64% Bought 0.00% shares Q3 2022	share	0.77%	118.32M	$37.31	$58.07	+55.64%	Bought 0.00% shares Q3 2022
Biotechnology AbCellera Biologics Inc. Portfolio share: 0.68% Portfolio value: 103.35M Avg. open price: N/A Current price: $11.91 P/L: N/A N/A Q4 2020	share	0.68%	103.35M	N/A	$11.91	N/A	N/A Q4 2020
Biotechnology argenx SE Portfolio share: 0.65% Portfolio value: 98.91M Avg. open price: $52.65 Current price: $393.21 P/L: +646.78% Sold -74.98% shares Q3 2022	share	0.65%	98.91M	$52.65	$393.21	+646.78%	Sold -74.98% shares Q3 2022
Biotechnology Mirati Therapeutics, Inc. Portfolio share: 0.64% Portfolio value: 98.45M Avg. open price: $37.92 Current price: $92.75 P/L: +144.62% Bought +7.85% shares Q1 2020	share	0.64%	98.45M	$37.92	$92.75	+144.62%	Bought +7.85% shares Q1 2020
Biotechnology Madrigal Pharmaceuticals, Inc. Portfolio share: 0.64% Portfolio value: 97.43M Avg. open price: $83.12 Current price: $72.87 P/L: -12.33% Bought 0.00% shares Q3 2020	share	0.64%	97.43M	$83.12	$72.87	-12.33%	Bought 0.00% shares Q3 2020
Biotechnology ChemoCentryx, Inc. Portfolio share: 0.61% Portfolio value: 92.60M Avg. open price: $17.74 Current price: $51.99 P/L: +193.13% Bought +95.52% shares Q2 2022	share	0.61%	92.60M	$17.74	$51.99	+193.13%	Bought +95.52% shares Q2 2022
Biotechnology Travere Therapeutics, Inc. Portfolio share: 0.53% Portfolio value: 81.31M Avg. open price: $19.73 Current price: $20.01 P/L: +1.43% Bought +23.64% shares Q1 2022	share	0.53%	81.31M	$19.73	$20.01	+1.43%	Bought +23.64% shares Q1 2022
Biotechnology Akero Therapeutics, Inc. Portfolio share: 0.53% Portfolio value: 80.64M Avg. open price: $9.45 Current price: $44.04 P/L: +366.03% Bought +1900.69% shares Q3 2022	share	0.53%	80.64M	$9.45	$44.04	+366.03%	Bought +1900.69% shares Q3 2022
Biotechnology Entrada Therapeutics, Inc. Portfolio share: 0.50% Portfolio value: 76.68M Avg. open price: $9.39 Current price: $17.96 P/L: +91.27% Bought +3.43% shares Q2 2022	share	0.50%	76.68M	$9.39	$17.96	+91.27%	Bought +3.43% shares Q2 2022
Biotechnology IGM Biosciences, Inc. Portfolio share: 0.47% Portfolio value: 71.77M Avg. open price: $86.88 Current price: $20.05 P/L: -76.92% Bought +0.36% shares Q1 2021	share	0.47%	71.77M	$86.88	$20.05	-76.92%	Bought +0.36% shares Q1 2021
Biotechnology Replimune Group, Inc. Portfolio share: 0.44% Portfolio value: 67.24M Avg. open price: $21.61 Current price: $19.95 P/L: -7.68% Bought +8.43% shares Q3 2022	share	0.44%	67.24M	$21.61	$19.95	-7.68%	Bought +8.43% shares Q3 2022
Biotechnology Prelude Therapeutics Incorporated Portfolio share: 0.44% Portfolio value: 66.91M Avg. open price: $71.55 Current price: $6.2 P/L: -91.33% Bought +0.05% shares Q1 2021	share	0.44%	66.91M	$71.55	$6.2	-91.33%	Bought +0.05% shares Q1 2021
Biotechnology Kymera Therapeutics, Inc. Portfolio share: 0.41% Portfolio value: 62.69M Avg. open price: $45.18 Current price: $29.11 P/L: -35.56% Bought +20.76% shares Q2 2022	share	0.41%	62.69M	$45.18	$29.11	-35.56%	Bought +20.76% shares Q2 2022
Drug Manufacturers—General Horizon Therapeutics Public Limited Company Portfolio share: 0.39% Portfolio value: 60.01M Avg. open price: $83.32 Current price: $98.48 P/L: +18.20% Sold -15.57% shares Q3 2022	share	0.39%	60.01M	$83.32	$98.48	+18.20%	Sold -15.57% shares Q3 2022
Medical Devices Cerus Corporation Portfolio share: 0.38% Portfolio value: 57.84M Avg. open price: $4.56 Current price: $3.99 P/L: -12.49% Bought +17.17% shares Q2 2022	share	0.38%	57.84M	$4.56	$3.99	-12.49%	Bought +17.17% shares Q2 2022
Biotechnology Nurix Therapeutics, Inc. Portfolio share: 0.33% Portfolio value: 50.58M Avg. open price: $20.01 Current price: $12.38 P/L: -38.12% Bought +58.19% shares Q2 2022	share	0.33%	50.58M	$20.01	$12.38	-38.12%	Bought +58.19% shares Q2 2022
Biotechnology Chinook Therapeutics, Inc. Portfolio share: 0.33% Portfolio value: 49.82M Avg. open price: $14.31 Current price: $22.77 P/L: +59.16% Bought +8.57% shares Q2 2022	share	0.33%	49.82M	$14.31	$22.77	+59.16%	Bought +8.57% shares Q2 2022
Biotechnology Verve Therapeutics, Inc. Portfolio share: 0.32% Portfolio value: 48.65M Avg. open price: N/A Current price: $21.42 P/L: N/A N/A Q2 2021	share	0.32%	48.65M	N/A	$21.42	N/A	N/A Q2 2021
Biotechnology Immatics N.V. Portfolio share: 0.29% Portfolio value: 44.23M Avg. open price: $10.82 Current price: $11.13 P/L: +2.89% Bought +3.29% shares Q3 2021	share	0.29%	44.23M	$10.82	$11.13	+2.89%	Bought +3.29% shares Q3 2021
Biotechnology Forma Therapeutics Holdings, Inc. Portfolio share: 0.25% Portfolio value: 37.64M Avg. open price: $49.84 Current price: $20.01 P/L: -59.85% Sold -6.82% shares Q3 2022	share	0.25%	37.64M	$49.84	$20.01	-59.85%	Sold -6.82% shares Q3 2022
Insmed Incorporated Portfolio share: 0.24% Portfolio value: 36.29M Avg. open price: N/A Current price: N/A P/L: N/A N/A Q2 2021	share	0.24%	36.29M	N/A	N/A	N/A	N/A Q2 2021
Biotechnology Kiniksa Pharmaceuticals, Ltd. Portfolio share: 0.24% Portfolio value: 35.94M Avg. open price: N/A Current price: $15.73 P/L: N/A Sold -6.68% shares Q2 2019	share	0.24%	35.94M	N/A	$15.73	N/A	Sold -6.68% shares Q2 2019
Biotechnology Heron Therapeutics, Inc. Portfolio share: 0.22% Portfolio value: 34.31M Avg. open price: $18.06 Current price: $2.54 P/L: -85.93% Bought +35.65% shares Q2 2021	share	0.22%	34.31M	$18.06	$2.54	-85.93%	Bought +35.65% shares Q2 2021
Biotechnology Aerovate Therapeutics, Inc. Portfolio share: 0.21% Portfolio value: 32.82M Avg. open price: $17.99 Current price: $18 P/L: +0.06% Sold -4.37% shares Q3 2022	share	0.21%	32.82M	$17.99	$18	+0.06%	Sold -4.37% shares Q3 2022
Biotechnology 2seventy bio, Inc. Portfolio share: 0.20% Portfolio value: 30.01M Avg. open price: $25.92 Current price: $15.36 P/L: -40.74% Bought +147.56% shares Q1 2022	share	0.20%	30.01M	$25.92	$15.36	-40.74%	Bought +147.56% shares Q1 2022
Biotechnology Krystal Biotech, Inc. Portfolio share: 0.19% Portfolio value: 29.42M Avg. open price: $28.89 Current price: $75.78 P/L: +162.28% Sold -47.73% shares Q3 2022	share	0.19%	29.42M	$28.89	$75.78	+162.28%	Sold -47.73% shares Q3 2022
Biotechnology Xenon Pharmaceuticals Inc. Portfolio share: 0.18% Portfolio value: 27.13M Avg. open price: $15.38 Current price: $38.83 P/L: +152.47% Bought +9.35% shares Q1 2021	share	0.18%	27.13M	$15.38	$38.83	+152.47%	Bought +9.35% shares Q1 2021
Biotechnology CinCor Pharma, Inc. Portfolio share: 0.17% Portfolio value: 26.49M Avg. open price: N/A Current price: $12.33 P/L: N/A N/A Q3 2022	share	0.17%	26.49M	N/A	$12.33	N/A	N/A Q3 2022
Biotechnology DBV Technologies S.A. Portfolio share: 0.17% Portfolio value: 25.86M Avg. open price: $8.74 Current price: $1.31 P/L: -85.02% Bought +165.25% shares Q4 2019	share	0.17%	25.86M	$8.74	$1.31	-85.02%	Bought +165.25% shares Q4 2019
Biotechnology IDEAYA Biosciences, Inc. Portfolio share: 0.16% Portfolio value: 24.89M Avg. open price: N/A Current price: $17.77 P/L: N/A N/A Q3 2022	share	0.16%	24.89M	N/A	$17.77	N/A	N/A Q3 2022
Biotechnology Design Therapeutics, Inc. Portfolio share: 0.16% Portfolio value: 24.02M Avg. open price: N/A Current price: $13.67 P/L: N/A N/A Q1 2021	share	0.16%	24.02M	N/A	$13.67	N/A	N/A Q1 2021
Biotechnology Verastem, Inc. Portfolio share: 0.15% Portfolio value: 22.94M Avg. open price: $2.2 Current price: $0.42 P/L: -80.92% Bought +25.58% shares Q1 2022	share	0.15%	22.94M	$2.2	$0.42	-80.92%	Bought +25.58% shares Q1 2022
Biotechnology Altimmune, Inc. Portfolio share: 0.15% Portfolio value: 22.59M Avg. open price: $8.62 Current price: $11.09 P/L: +28.70% Sold -14.73% shares Q3 2022	share	0.15%	22.59M	$8.62	$11.09	+28.70%	Sold -14.73% shares Q3 2022
Diagnostics & Research Invitae Corporation Portfolio share: 0.14% Portfolio value: 20.66M Avg. open price: $25.11 Current price: $2.73 P/L: -89.13% Sold -14.90% shares Q3 2022	share	0.14%	20.66M	$25.11	$2.73	-89.13%	Sold -14.90% shares Q3 2022
Biotechnology Biomea Fusion, Inc. Portfolio share: 0.13% Portfolio value: 20.58M Avg. open price: $7.61 Current price: $6.77 P/L: -11.03% Bought +35.65% shares Q2 2022	share	0.13%	20.58M	$7.61	$6.77	-11.03%	Bought +35.65% shares Q2 2022
Biotechnology Bicycle Therapeutics plc Portfolio share: 0.13% Portfolio value: 19.62M Avg. open price: N/A Current price: $32.41 P/L: N/A N/A Q3 2022	share	0.13%	19.62M	N/A	$32.41	N/A	N/A Q3 2022
Biotechnology Ultragenyx Pharmaceutical Inc. Portfolio share: 0.13% Portfolio value: 19.50M Avg. open price: $72.62 Current price: $39.83 P/L: -45.15% Bought +5.97% shares Q2 2022	share	0.13%	19.50M	$72.62	$39.83	-45.15%	Bought +5.97% shares Q2 2022
Biotechnology Instil Bio, Inc. Portfolio share: 0.12% Portfolio value: 18.84M Avg. open price: N/A Current price: $1.22 P/L: N/A N/A Q1 2021	share	0.12%	18.84M	N/A	$1.22	N/A	N/A Q1 2021
Biotechnology Veru Inc. Portfolio share: 0.12% Portfolio value: 18.54M Avg. open price: N/A Current price: $5.82 P/L: N/A N/A Q3 2022	share	0.12%	18.54M	N/A	$5.82	N/A	N/A Q3 2022
Biotechnology Relmada Therapeutics, Inc. Portfolio share: 0.12% Portfolio value: 18.32M Avg. open price: $27.93 Current price: $4.45 P/L: -84.07% Bought +146.33% shares Q4 2021	share	0.12%	18.32M	$27.93	$4.45	-84.07%	Bought +146.33% shares Q4 2021
Drug Manufacturers—Specialty & Generic Alkermes plc Portfolio share: 0.12% Portfolio value: 18.19M Avg. open price: $24.85 Current price: $25.51 P/L: +2.66% Sold -45.67% shares Q3 2022	share	0.12%	18.19M	$24.85	$25.51	+2.66%	Sold -45.67% shares Q3 2022
Biotechnology Denali Therapeutics Inc. Portfolio share: 0.12% Portfolio value: 18.06M Avg. open price: $32.17 Current price: $30.94 P/L: -3.82% Bought +563.46% shares Q2 2022	share	0.12%	18.06M	$32.17	$30.94	-3.82%	Bought +563.46% shares Q2 2022
Biotechnology Opthea Limited Portfolio share: 0.11% Portfolio value: 16.68M Avg. open price: $9.57 Current price: $4.9 P/L: -48.80% Sold -0.18% shares Q3 2022	share	0.11%	16.68M	$9.57	$4.9	-48.80%	Sold -0.18% shares Q3 2022
Biotechnology bluebird bio, Inc. Portfolio share: 0.10% Portfolio value: 15.82M Avg. open price: $23.53 Current price: $8.01 P/L: -65.96% Sold -35.23% shares Q4 2021	share	0.10%	15.82M	$23.53	$8.01	-65.96%	Sold -35.23% shares Q4 2021
Biotechnology Crinetics Pharmaceuticals, Inc. Portfolio share: 0.09% Portfolio value: 14.44M Avg. open price: $15.85 Current price: $18.32 P/L: +15.56% Sold -11.09% shares Q3 2022	share	0.09%	14.44M	$15.85	$18.32	+15.56%	Sold -11.09% shares Q3 2022
Biotechnology Aadi Bioscience, Inc. Portfolio share: 0.09% Portfolio value: 13.98M Avg. open price: N/A Current price: $13.42 P/L: N/A N/A Q3 2022	share	0.09%	13.98M	N/A	$13.42	N/A	N/A Q3 2022
Biotechnology Tricida, Inc. Portfolio share: 0.09% Portfolio value: 13.83M Avg. open price: $20.67 Current price: $0.23 P/L: -98.90% Sold -12.16% shares Q3 2022	share	0.09%	13.83M	$20.67	$0.23	-98.90%	Sold -12.16% shares Q3 2022
Biotechnology Affimed N.V. Portfolio share: 0.09% Portfolio value: 13.58M Avg. open price: $5.58 Current price: $2.12 P/L: -62.12% Bought +28.02% shares Q2 2022	share	0.09%	13.58M	$5.58	$2.12	-62.12%	Bought +28.02% shares Q2 2022
Biotechnology DICE Therapeutics, Inc. Portfolio share: 0.08% Portfolio value: 11.92M Avg. open price: N/A Current price: $34.51 P/L: N/A N/A Q3 2021	share	0.08%	11.92M	N/A	$34.51	N/A	N/A Q3 2021
Biotechnology AnaptysBio, Inc. Portfolio share: 0.07% Portfolio value: 10.89M Avg. open price: $21.95 Current price: $28.65 P/L: +30.54% Sold -12.33% shares Q4 2020	share	0.07%	10.89M	$21.95	$28.65	+30.54%	Sold -12.33% shares Q4 2020
Biotechnology FibroGen, Inc. Portfolio share: 0.07% Portfolio value: 10.61M Avg. open price: $12.03 Current price: $16.19 P/L: +34.53% Bought +40.22% shares Q2 2022	share	0.07%	10.61M	$12.03	$16.19	+34.53%	Bought +40.22% shares Q2 2022
Biotechnology Adaptimmune Therapeutics plc Portfolio share: 0.07% Portfolio value: 10.56M Avg. open price: $5.56 Current price: $1.95 P/L: -64.92% Bought +55.30% shares Q4 2020	share	0.07%	10.56M	$5.56	$1.95	-64.92%	Bought +55.30% shares Q4 2020
Biotechnology Zymeworks Inc. Portfolio share: 0.07% Portfolio value: 10.50M Avg. open price: $15.7 Current price: $7.62 P/L: -51.46% Bought +30.31% shares Q4 2018	share	0.07%	10.50M	$15.7	$7.62	-51.46%	Bought +30.31% shares Q4 2018
Biotechnology POINT Biopharma Global Inc. Portfolio share: 0.06% Portfolio value: 9.03M Avg. open price: N/A Current price: $6.72 P/L: N/A N/A Q3 2022	share	0.06%	9.03M	N/A	$6.72	N/A	N/A Q3 2022
Biotechnology TScan Therapeutics, Inc. Portfolio share: 0.06% Portfolio value: 8.49M Avg. open price: $2.8 Current price: $2.21 P/L: -21.07% Bought +95.42% shares Q2 2022	share	0.06%	8.49M	$2.8	$2.21	-21.07%	Bought +95.42% shares Q2 2022
Invitae Corporation Portfolio share: 0.05% Portfolio value: 8.14M Avg. open price: N/A Current price: N/A P/L: N/A N/A Q3 2020	share	0.05%	8.14M	N/A	N/A	N/A	N/A Q3 2020
Biotechnology CymaBay Therapeutics, Inc. Portfolio share: 0.05% Portfolio value: 7.59M Avg. open price: $6.27 Current price: $4.17 P/L: -33.50% Sold -24.98% shares Q1 2021	share	0.05%	7.59M	$6.27	$4.17	-33.50%	Sold -24.98% shares Q1 2021
Biotechnology Vera Therapeutics, Inc. Portfolio share: 0.05% Portfolio value: 7.10M Avg. open price: N/A Current price: $16.19 P/L: N/A N/A Q1 2022	share	0.05%	7.10M	N/A	$16.19	N/A	N/A Q1 2022
Medical Devices Pacific Biosciences of California, Inc. Portfolio share: 0.04% Portfolio value: 6.54M Avg. open price: $34.97 Current price: $10.03 P/L: -71.32% Sold -79.29% shares Q3 2022	share	0.04%	6.54M	$34.97	$10.03	-71.32%	Sold -79.29% shares Q3 2022
Diagnostics & Research Fulgent Genetics, Inc. Portfolio share: 0.04% Portfolio value: 6.35M Avg. open price: $10.39 Current price: $35.93 P/L: +245.81% Sold -17.29% shares Q3 2022	share	0.04%	6.35M	$10.39	$35.93	+245.81%	Sold -17.29% shares Q3 2022
Biotechnology Amarin Corporation plc Portfolio share: 0.04% Portfolio value: 5.86M Avg. open price: $5.46 Current price: $1.18 P/L: -78.48% Sold -74.60% shares Q3 2022	share	0.04%	5.86M	$5.46	$1.18	-78.48%	Sold -74.60% shares Q3 2022
Biotechnology Achilles Therapeutics plc Portfolio share: 0.04% Portfolio value: 5.85M Avg. open price: N/A Current price: $1.71 P/L: N/A N/A Q1 2021	share	0.04%	5.85M	N/A	$1.71	N/A	N/A Q1 2021
Biotechnology Vor Biopharma Inc. Portfolio share: 0.04% Portfolio value: 5.83M Avg. open price: $4.97 Current price: $4.72 P/L: -5.03% Bought +28.73% shares Q3 2022	share	0.04%	5.83M	$4.97	$4.72	-5.03%	Bought +28.73% shares Q3 2022
Biotechnology Reata Pharmaceuticals, Inc. Portfolio share: 0.04% Portfolio value: 5.62M Avg. open price: $106.06 Current price: $39.62 P/L: -62.64% Bought +321.14% shares Q4 2020	share	0.04%	5.62M	$106.06	$39.62	-62.64%	Bought +321.14% shares Q4 2020
Biotechnology Atreca, Inc. Portfolio share: 0.04% Portfolio value: 5.54M Avg. open price: N/A Current price: $1 P/L: N/A N/A Q2 2019	share	0.04%	5.54M	N/A	$1	N/A	N/A Q2 2019
Biotechnology Nkarta, Inc. Portfolio share: 0.03% Portfolio value: 5.26M Avg. open price: N/A Current price: $8.15 P/L: N/A N/A Q2 2022	share	0.03%	5.26M	N/A	$8.15	N/A	N/A Q2 2022
Medical Devices Talis Biomedical Corporation Portfolio share: 0.03% Portfolio value: 5.19M Avg. open price: $6.25 Current price: $0.56 P/L: -91.04% Bought +0.66% shares Q4 2021	share	0.03%	5.19M	$6.25	$0.56	-91.04%	Bought +0.66% shares Q4 2021
Biotechnology Kronos Bio, Inc. Portfolio share: 0.03% Portfolio value: 5.15M Avg. open price: N/A Current price: $1.77 P/L: N/A N/A Q3 2022	share	0.03%	5.15M	N/A	$1.77	N/A	N/A Q3 2022
Biotechnology Cyteir Therapeutics, Inc. Portfolio share: 0.03% Portfolio value: 5.07M Avg. open price: $3.77 Current price: $1.36 P/L: -63.93% Bought +225.32% shares Q2 2022	share	0.03%	5.07M	$3.77	$1.36	-63.93%	Bought +225.32% shares Q2 2022
Biotechnology Surrozen, Inc. Portfolio share: 0.03% Portfolio value: 5.05M Avg. open price: N/A Current price: $0.54 P/L: N/A N/A Q3 2021	share	0.03%	5.05M	N/A	$0.54	N/A	N/A Q3 2021
Biotechnology Edgewise Therapeutics, Inc. Portfolio share: 0.03% Portfolio value: 4.92M Avg. open price: N/A Current price: $8.83 P/L: N/A N/A Q1 2021	share	0.03%	4.92M	N/A	$8.83	N/A	N/A Q1 2021
Biotechnology Fate Therapeutics, Inc. Portfolio share: 0.03% Portfolio value: 4.83M Avg. open price: N/A Current price: $20.4 P/L: N/A N/A Q3 2022	share	0.03%	4.83M	N/A	$20.4	N/A	N/A Q3 2022
Biotechnology Stoke Therapeutics, Inc. Portfolio share: 0.03% Portfolio value: 4.74M Avg. open price: N/A Current price: $7.16 P/L: N/A N/A Q3 2022	share	0.03%	4.74M	N/A	$7.16	N/A	N/A Q3 2022
Biotechnology Revolution Medicines, Inc. Portfolio share: 0.03% Portfolio value: 4.38M Avg. open price: N/A Current price: $24.32 P/L: N/A N/A Q1 2021	share	0.03%	4.38M	N/A	$24.32	N/A	N/A Q1 2021
Diagnostics & Research Natera, Inc. Portfolio share: 0.03% Portfolio value: 4.38M Avg. open price: $10.8 Current price: $40.39 P/L: +273.98% N/A Q2 2022	share	0.03%	4.38M	$10.8	$40.39	+273.98%	N/A Q2 2022
Biotechnology Allakos Inc. Portfolio share: 0.03% Portfolio value: 4.30M Avg. open price: $94.83 Current price: $8.14 P/L: -91.42% Sold -1.57% shares Q1 2021	share	0.03%	4.30M	$94.83	$8.14	-91.42%	Sold -1.57% shares Q1 2021
Biotechnology Eiger BioPharmaceuticals, Inc. Portfolio share: 0.03% Portfolio value: 4.06M Avg. open price: N/A Current price: $4.14 P/L: N/A N/A Q3 2022	share	0.03%	4.06M	N/A	$4.14	N/A	N/A Q3 2022
Biotechnology PMV Pharmaceuticals, Inc. Portfolio share: 0.03% Portfolio value: 3.83M Avg. open price: N/A Current price: $9.89 P/L: N/A N/A Q3 2022	share	0.03%	3.83M	N/A	$9.89	N/A	N/A Q3 2022
Biotechnology Century Therapeutics, Inc. Portfolio share: 0.02% Portfolio value: 3.66M Avg. open price: N/A Current price: $10.25 P/L: N/A N/A Q3 2022	share	0.02%	3.66M	N/A	$10.25	N/A	N/A Q3 2022
Biotechnology HOOKIPA Pharma Inc. Portfolio share: 0.02% Portfolio value: 3.21M Avg. open price: $2.46 Current price: $0.95 P/L: -61.38% Bought +242.69% shares Q1 2022	share	0.02%	3.21M	$2.46	$0.95	-61.38%	Bought +242.69% shares Q1 2022
Biotechnology MacroGenics, Inc. Portfolio share: 0.02% Portfolio value: 3.08M Avg. open price: $15.12 Current price: $6.38 P/L: -57.81% Bought +101.68% shares Q2 2022	share	0.02%	3.08M	$15.12	$6.38	-57.81%	Bought +101.68% shares Q2 2022
Biotechnology Athira Pharma, Inc. Portfolio share: 0.02% Portfolio value: 3.09M Avg. open price: $13.5 Current price: $2.94 P/L: -78.22% Bought +29.08% shares Q2 2022	share	0.02%	3.09M	$13.5	$2.94	-78.22%	Bought +29.08% shares Q2 2022
Biotechnology iTeos Therapeutics, Inc. Portfolio share: 0.02% Portfolio value: 2.86M Avg. open price: N/A Current price: $20.04 P/L: N/A Sold -10.27% shares Q4 2020	share	0.02%	2.86M	N/A	$20.04	N/A	Sold -10.27% shares Q4 2020
Biotechnology Atara Biotherapeutics, Inc. Portfolio share: 0.02% Portfolio value: 2.81M Avg. open price: N/A Current price: $4.65 P/L: N/A N/A Q2 2022	share	0.02%	2.81M	N/A	$4.65	N/A	N/A Q2 2022
Biotechnology Tango Therapeutics, Inc. Portfolio share: 0.02% Portfolio value: 2.71M Avg. open price: N/A Current price: $7.69 P/L: N/A N/A Q3 2021	share	0.02%	2.71M	N/A	$7.69	N/A	N/A Q3 2021
Biotechnology Syndax Pharmaceuticals, Inc. Portfolio share: 0.02% Portfolio value: 2.66M Avg. open price: N/A Current price: $25.44 P/L: N/A N/A Q3 2021	share	0.02%	2.66M	N/A	$25.44	N/A	N/A Q3 2021
Biotechnology Otonomy, Inc. Portfolio share: 0.02% Portfolio value: 2.49M Avg. open price: $2.27 Current price: $0.13 P/L: -94.22% Bought +0.36% shares Q3 2022	share	0.02%	2.49M	$2.27	$0.13	-94.22%	Bought +0.36% shares Q3 2022
Drug Manufacturers—Specialty & Generic Neoleukin Therapeutics, Inc. Portfolio share: 0.02% Portfolio value: 2.44M Avg. open price: $16.6 Current price: $0.43 P/L: -97.40% Bought +12.48% shares Q3 2020	share	0.02%	2.44M	$16.6	$0.43	-97.40%	Bought +12.48% shares Q3 2020
Biotechnology Aligos Therapeutics, Inc. Portfolio share: 0.01% Portfolio value: 2.28M Avg. open price: $20.39 Current price: $0.97 P/L: -95.26% Bought +28.97% shares Q3 2021	share	0.01%	2.28M	$20.39	$0.97	-95.26%	Bought +28.97% shares Q3 2021
Biotechnology Alector, Inc. Portfolio share: 0.01% Portfolio value: 2.26M Avg. open price: N/A Current price: $8.68 P/L: N/A Sold -9.93% shares Q4 2020	share	0.01%	2.26M	N/A	$8.68	N/A	Sold -9.93% shares Q4 2020
Biotechnology Aeglea BioTherapeutics, Inc. Portfolio share: 0.01% Portfolio value: 1.79M Avg. open price: $5.99 Current price: $0.47 P/L: -92.14% Sold -22.14% shares Q4 2020	share	0.01%	1.79M	$5.99	$0.47	-92.14%	Sold -22.14% shares Q4 2020
Biotechnology TCR2 Therapeutics Inc. Portfolio share: 0.01% Portfolio value: 1.35M Avg. open price: $10.8 Current price: $1.37 P/L: -87.31% Bought +326.76% shares Q4 2021	share	0.01%	1.35M	$10.8	$1.37	-87.31%	Bought +326.76% shares Q4 2021
Biotechnology aTyr Pharma, Inc. Portfolio share: 0.00% Portfolio value: 604K Avg. open price: N/A Current price: $2.29 P/L: N/A Sold -46.22% shares Q3 2022	share	0.00%	604K	N/A	$2.29	N/A	Sold -46.22% shares Q3 2022
Biotechnology Protara Therapeutics, Inc. Portfolio share: 0.00% Portfolio value: 591K Avg. open price: N/A Current price: $3.63 P/L: N/A N/A Q2 2020	share	0.00%	591K	N/A	$3.63	N/A	N/A Q2 2020
Biotechnology Kezar Life Sciences, Inc. Portfolio share: 0.00% Portfolio value: 533K Avg. open price: N/A Current price: $7.07 P/L: N/A Sold -55.65% shares Q2 2022	share	0.00%	533K	N/A	$7.07	N/A	Sold -55.65% shares Q2 2022
Biotechnology Leap Therapeutics, Inc. Portfolio share: 0.00% Portfolio value: 493K Avg. open price: N/A Current price: $0.52 P/L: N/A Sold -42.80% shares Q3 2020	share	0.00%	493K	N/A	$0.52	N/A	Sold -42.80% shares Q3 2020
Biotechnology Insmed Incorporated Portfolio share: 0.00% Portfolio value: 430K Avg. open price: $21.82 Current price: $19.89 P/L: -8.84% Sold -99.07% shares Q3 2022	share	0.00%	430K	$21.82	$19.89	-8.84%	Sold -99.07% shares Q3 2022
Biotechnology Cabaletta Bio, Inc. Portfolio share: 0.00% Portfolio value: 430K Avg. open price: $8.6 Current price: $4.97 P/L: -42.21% Bought +4.04% shares Q3 2021	share	0.00%	430K	$8.6	$4.97	-42.21%	Bought +4.04% shares Q3 2021
Biotechnology Foghorn Therapeutics Inc. Portfolio share: 0.00% Portfolio value: 386K Avg. open price: N/A Current price: $6.73 P/L: N/A N/A Q4 2021	share	0.00%	386K	N/A	$6.73	N/A	N/A Q4 2021
Diagnostics & Research Genetron Holdings Limited Portfolio share: 0.00% Portfolio value: 356K Avg. open price: $11.94 Current price: $1.1 P/L: -90.79% Bought +355.31% shares Q4 2020	share	0.00%	356K	$11.94	$1.1	-90.79%	Bought +355.31% shares Q4 2020
Biotechnology Vincerx Pharma, Inc. Portfolio share: 0.00% Portfolio value: 333K Avg. open price: N/A Current price: $0.7 P/L: N/A N/A Q3 2021	share	0.00%	333K	N/A	$0.7	N/A	N/A Q3 2021
Diagnostics & Research Sera Prognostics, Inc. Portfolio share: 0.00% Portfolio value: 322K Avg. open price: N/A Current price: $1.25 P/L: N/A N/A Q3 2021	share	0.00%	322K	N/A	$1.25	N/A	N/A Q3 2021
Biotechnology Bellicum Pharmaceuticals, Inc. Portfolio share: 0.00% Portfolio value: 299K Avg. open price: $136.2 Current price: $0.99 P/L: -99.27% N/A Q1 2020	share	0.00%	299K	$136.2	$0.99	-99.27%	N/A Q1 2020
Biotechnology Surrozen, Inc. Portfolio share: 0.00% Portfolio value: 154K Avg. open price: N/A Current price: $0.05 P/L: N/A N/A Q3 2021	share	0.00%	154K	N/A	$0.05	N/A	N/A Q3 2021
Biotechnology LogicBio Therapeutics, Inc. Portfolio share: 0.00% Portfolio value: 38K Avg. open price: N/A Current price: $2.07 P/L: N/A Sold -69.19% shares Q3 2022	share	0.00%	38K	N/A	$2.07	N/A	Sold -69.19% shares Q3 2022
Biotechnology NexImmune, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: N/A Current price: $0.41 P/L: N/A Sold -100.00% shares Q3 2022	share	0.00%	0	N/A	$0.41	N/A	Sold -100.00% shares Q3 2022
Biotechnology BioAtla, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: N/A Current price: $10.52 P/L: N/A Sold -100.00% shares Q3 2022	share	0.00%	0	N/A	$10.52	N/A	Sold -100.00% shares Q3 2022
Biotechnology Harmony Biosciences Holdings, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: N/A Current price: $60.91 P/L: N/A Sold -100.00% shares Q3 2022	share	0.00%	0	N/A	$60.91	N/A	Sold -100.00% shares Q3 2022
Biotechnology Epizyme, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: N/A Current price: $1.46 P/L: N/A Sold -100.00% shares Q3 2022	share	0.00%	0	N/A	$1.46	N/A	Sold -100.00% shares Q3 2022
Biotechnology Evofem Biosciences, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: $3.49 Current price: $0.07 P/L: -98.00% Sold -100.00% shares Q3 2022	share	0.00%	0	$3.49	$0.07	-98.00%	Sold -100.00% shares Q3 2022
Biotechnology Passage Bio, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: N/A Current price: $1.16 P/L: N/A Sold -100.00% shares Q3 2022	share	0.00%	0	N/A	$1.16	N/A	Sold -100.00% shares Q3 2022
Biotechnology Legend Biotech Corporation Portfolio share: 0.00% Portfolio value: 0 Avg. open price: $33.7 Current price: $50.99 P/L: +51.31% Sold -100.00% shares Q3 2022	share	0.00%	0	$33.7	$50.99	+51.31%	Sold -100.00% shares Q3 2022
Diagnostics & Research Burning Rock Biotech Limited Portfolio share: 0.00% Portfolio value: 0 Avg. open price: N/A Current price: $2.41 P/L: N/A Sold -100.00% shares Q3 2022	share	0.00%	0	N/A	$2.41	N/A	Sold -100.00% shares Q3 2022
Biotechnology Centessa Pharmaceuticals plc Portfolio share: 0.00% Portfolio value: 0 Avg. open price: $22.21 Current price: $3.93 P/L: -82.31% Sold -100.00% shares Q3 2022	share	0.00%	0	$22.21	$3.93	-82.31%	Sold -100.00% shares Q3 2022
Sarepta Therapeutics, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: N/A Current price: N/A P/L: N/A Sold -100.00% shares Q3 2022	share	0.00%	0	N/A	N/A	N/A	Sold -100.00% shares Q3 2022
Biotechnology Karuna Therapeutics, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: $72 Current price: $226.95 P/L: +215.21% Sold -100.00% shares Q3 2022	share	0.00%	0	$72	$226.95	+215.21%	Sold -100.00% shares Q3 2022
Biotechnology Merus N.V. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: $17.42 Current price: $14.2 P/L: -18.49% Sold -100.00% shares Q3 2022	share	0.00%	0	$17.42	$14.2	-18.49%	Sold -100.00% shares Q3 2022
Biotechnology NGM Biopharmaceuticals, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: $30.3 Current price: $5.6 P/L: -81.52% Sold -100.00% shares Q3 2022	share	0.00%	0	$30.3	$5.6	-81.52%	Sold -100.00% shares Q3 2022
Biotechnology Inozyme Pharma, Inc. Portfolio share: 0.00% Portfolio value: 0 Avg. open price: N/A Current price: $1.36 P/L: N/A Sold -100.00% shares Q3 2022	share	0.00%	0	N/A	$1.36	N/A	Sold -100.00% shares Q3 2022

Showing TOP 129 BAKER BROS. ADVISORS LP's 13F holdings.

Frequently Asked Questions (FAQ)

What is the biggest position of BAKER BROS. ADVISORS LP?

The biggest position of the BAKER BROS. ADVISORS LP is Seagen Inc. (SGEN) with 42.04% portfolio share worth of 6.42B US dollars.

Top 5 BAKER BROS. ADVISORS LP's holdings represent 76.84% of the portfolio:

Seagen Inc. (SGEN) – 42.04%
Incyte Corporation (INCY) – 15.78%
BeiGene, Ltd. (BGNE) – 10.3%
ACADIA Pharmaceuticals Inc. (ACAD) – 4.49%
BioMarin Pharmaceutical Inc. (BMRN) – 4.23%

Who is the portfolio manager of BAKER BROS. ADVISORS LP?

The portfolio manager of the BAKER BROS. ADVISORS LP is .

What is the total asset value of the BAKER BROS. ADVISORS LP portfolio?

BAKER BROS. ADVISORS LP total asset value (portfolio value) is 15.27B US dollars.

Who is ?

is the portfolio manager of the BAKER BROS. ADVISORS LP.

What is (BAKER BROS. ADVISORS LP) fund performance?

BAKER BROS. ADVISORS LP's quarterly performance is -11.67%, annualy -33.99%. In the past 3 years, the value of 's portfolio has increased by +4%. In the past 5 years, the value of the portfolio has increased by +8%.

What is the BAKER BROS. ADVISORS LP CIK?

BAKER BROS. ADVISORS LP's Central Index Key is 0001263508 .

BAKER BROS. ADVISORS LP Holdings

BAKER BROS. ADVISORS LP portfolio value:

BAKER BROS. ADVISORS LP quarter portfolio value change:

BAKER BROS. ADVISORS LP 1 year portfolio value change:

BAKER BROS. ADVISORS LP 3 years portfolio value change:

BAKER BROS. ADVISORS LP 5 years portfolio value change: