Alnylam Pharmaceuticals, Inc.
Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof

Abstract:

The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Patatin-Like Phospholipase Domain Containing 3 (PNPLA3) gene, and methods of using such RNAi agents to inhibit expression of a PNPLA3 gene and methods of treating subjects having Nonalcoholic Fatty Liver Disease (NAFLD) and/or a PNPLA3-associated disorder.