Alnylam Pharmaceuticals, Inc.
CHIRALLY-ENRICHED DOUBLE-STRANDED RNA AGENTS

Abstract:

The present invention relates to a chirally-modified dsRNA agent capable of inhibiting the expression of a target gene. The sense and antisense strands of chirally-modified dsRNA agent independently or in combination comprises one or more site specific-site specific/position specific, chirally-modified internucleotide linkages.