bluebird bio, Inc.
IL-10 RECEPTOR ALPHA HOMING ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE

Abstract:

The invention provides improved genome editing compositions and methods for editing an IL-10R.alpha. gene. The invention further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of, a cancer, GVHD, a transplant rejection, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.