Geron Corporation
Phosphorodiamidate backbone linkage for oligonucleotides

Abstract:

This invention relates to antisense oligonucleotides comprising at least one N3'.fwdarw.P5' phosphorodiamidate linkage (NPN) in the backbone, useful for modulating gene expression involved in the pathogenesis of a disease. Compounds useful as building blocks of said antisense oligonucleotides and methods of preparing building block compounds including NPN linkages are provided.