Ionis Pharmaceuticals, Inc.
Oligomeric compounds comprising .alpha.-.beta.-constrained nucleic acid

Abstract:

The present disclosure provides oligomeric compounds comprising at least one .alpha.-.beta.-constrained nucleic acid as provided herein. More particularly, the .alpha.-.beta.-constrained nucleic acid provided herein comprise an optionally modified nucleoside with a phosphorus containing constrained internucleoside linkage such as for example a cyclic phosphate internucleoside linkage. The .alpha.-.beta.-constrained nucleic acid provided herein are expected to be useful for enhancing one or more properties of oligomeric compounds they are incorporated into such as for example nuclease resistance. In certain embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.