Ionis Pharmaceuticals, Inc.
Oligomeric Compounds Comprising Bicyclic Nucleotides and Uses Thereof

Abstract:

The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.