Ionis Pharmaceuticals, Inc.
Single-Stranded RNAI Oligonucleotides Targeting APOC-III

Abstract:

The present disclosure pertains generally to chemically-modified oligonucleotides for use in research, diagnostics, and/or therapeutics. In certain embodiments, the present disclosure describes compounds and methods for the modulation of a target nucleic acid. In certain embodiments, the present disclosure describes compounds and methods for the modulation of Apoliprotein C-III expression.