Iovance Biotherapeutics, Inc.
PROCESSES FOR PRODUCTION OF TUMOR INFILTRATING LYMPHOCYTES AND USES OF SAME IN IMMUNOTHERAPY

Abstract:

The present invention provides improved and/or shortened methods for expanding TLs and producing therapeutic populations of TTLs, including novel methods for expanding TIL populations in a closed system that lead to improved efficacy, improved phenotype, and increased metabolic health of the TLs in a shorter time period, while allowing for reduced microbial contamination as well as decreased costs. Such TLs find use in therapeutic treatment regimens.