Sorrento Therapeutics, Inc.
Chemically-locked bispecific antibodies

Abstract:

Provided are bispecific antibody compounds having the Formula I: ##STR00001## wherein, FAB.sup.1, FAB.sup.2, and --X-- are as defined herein. The provided bispecific antibody compounds can be used a modulators of target molecules, including CD3, PSMA, CD19, CXCR5, CD33, PDL1, VEGFR2, cMet, or Ax1, and are useful in the treatment of one or more conditions.