Alexion Pharmaceuticals, Inc.
ASSAY FOR C5B-9 DEPOSITION IN COMPLEMENT-ASSOCIATED DISORDERS

Abstract:

Provided herein are methods of detecting C5b-9 deposition on endothelial cells. The methods are useful for screening patients for complement-associated disorders, for example, atypical hemolytic-uremic syndrome, as well as monitoring the efficacy of anti-C5 antibody therapy in a patient with a complement-associated disorder.