Regeneron Pharmaceuticals, Inc.
Genetically modified rodent with an inducible ACVR1 mutation in exon 7 that causes ectopic bone formation

Abstract:

A genetically modified rodent is provided that comprises a modified Acvr1 gene that comprises a conditional altered exon 7 encoding R258G in anti sense orientation, flanked by site-specific recombinase recognition sites, wherein the altered exon is inverted to sense orientation upon action of a recombinase, resulting in ectopic bone formation.