Regeneron Pharmaceuticals, Inc.
Humanized T cell co-receptor mice

Abstract:

The invention provides genetically modified non-human animals that express chimeric human/non-human T cell co-receptor polypeptides (e.g., CD4, CD8.alpha., CD8.beta.), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same.