Regeneron Pharmaceuticals, Inc.
Stabilized Formulations Containing Anti-CD20 x Anti-CD3 Bispecific Antibodies

Abstract:

The present invention provides stable liquid pharmaceutical formulations comprising a human bispecific antibody that specifically binds to human CD20 and human CD3. In certain embodiments, the formulations contain, in addition to the bispecific antibody, a buffer, a surfactant, and a sugar. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability upon stress and storage.