Regeneron Pharmaceuticals, Inc.
FORMULATION OPTIMIZATION FOR BISPECIFIC ANTIBODIES

Abstract:

The present invention provides methods and systems for formulation optimization of bispecific antibodies. The present application also provides methods and systems to select molecule candidates for constructing bispecific antibodies and formulation optimization thereof. Physico-chemical parameters of a bispecific antibody are characterized. The formulation optimization strategies are guided by the prediction of interaction parameters. Various formulation optimization strategies are provided based on these physico-chemical parameters.