Regeneron Pharmaceuticals, Inc.
GENETICALLY MODIFIED MAJOR HISTOCOMPATIBILITY COMPLEX ANIMALS

Abstract:

The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized .beta.2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.