Regeneron Pharmaceuticals, Inc.
RODENT MODEL OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA

Abstract:

A genetically modified rodent is provided that comprises a modified Acvr1 gene that comprises a conditional altered exon 7 encoding R258G in anti sense orientation, flanked by site-specific recombinase recognition sites, wherein the altered exon is inverted to sense orientation upon action of a recombinase, resulting in ectopic bone formation.