Arbutus Biopharma Corporation
Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same

Abstract:

The present invention includes novel substituted bicyclic (such as 4-substituted-chromane-8-carboxamide compounds), and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.