Arbutus Biopharma Corporation
Substituted 1-hydroxy-pyridin-2(1H)-ones, and methods of making and using same

Abstract:

The present invention includes novel substituted 1-hydroxy-pyridin-2(1H)-ones, which can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention inhibit HBV RNAse H activity.