Arbutus Biopharma Corporation
Substituted pyridinone-containing trycyclic compounds, and methods using same

Abstract:

The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.