Aclaris Therapeutics, Inc.
SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS

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Abstract:

The present invention relates to new pyrrolopyridine compounds having the structures of Formula (I)-(IV), wherein the R groups, A, B, C, D and n are as defined in the detailed description, and compositions and their application as pharmaceuticals for the treatment of disease. ##STR00001## Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Status:
Application
Type:

Utility

Filling date:

4 May 2020

Issue date:

5 Nov 2020