Aclaris Therapeutics, Inc.
Pyrrolopyrimidine ITK inhibitors

Abstract:

Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): ##STR00001## wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.