Adagene Inc.
DYNAMIC HUMAN HEAVY CHAIN ANTIBODY LIBRARIES
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Abstract:
Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody heavy chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.
Status:
Application
Type:
Utility
Filling date:
21 Aug 2017
Issue date:
6 Aug 2020