Adaptive Biotechnologies Corporation
Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
Last updated:
Abstract:
Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject. TCR and/or IG sequence diversity and sequence distribution permit immunocompetence and immune repertoire assessment and reflect the degree of T cell or B cell clonality and clonal expansion in the sample. Methods for stratifying patient populations on the basis of immunocompetence including likelihood of responding to immunotherapy are also described.
Status:
Grant
Type:
Utility
Filling date:
11 May 2018
Issue date:
23 Nov 2021