Applied Genetic Technologies Corporation
RECOMBINANT AAV PRODUCTION IN MAMMALIAN CELLS

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Abstract:

The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.

Status:
Application
Type:

Utility

Filling date:

15 Mar 2021

Issue date:

4 Nov 2021