Applied Genetic Technologies Corporation
RECOMBINANT AAV PRODUCTION IN MAMMALIAN CELLS
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Abstract:
The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
Status:
Application
Type:
Utility
Filling date:
15 Mar 2021
Issue date:
4 Nov 2021