Aligos Therapeutics, Inc.
Modulators of THR-.beta. and methods of use thereof

Abstract:

Disclosed herein are compounds of Formula I: TL-L.sub.a-CE-HD (I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IIa, IIb, IIIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds. ##STR00001## ##STR00002##