Aligos Therapeutics, Inc.
Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof

Abstract:

Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2'-O-methyl nucleotides and 2'-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5'-stabilized end cap; and (b) a short interfering nucleic acid (siNA).