Allogene Therapeutics, Inc.
CHIMERIC CYTOKINE RECEPTORS COMPRISING TGF BETA BINDING DOMAINS

Abstract:

Provided herein are chimeric cytokine receptors bearing a binding domain capable of binding a TGF-.beta. ligand or a TGF-.beta. receptor antibody. When present on chimeric antigen receptor (CAR)-bearing immune cells (CAR-T-cells), such receptors allow for increased CAR-T cell expansion, activity and persistence, constitutively and/or through engagement of a TGF-.beta. ligand or a TGF-.beta. receptor antibody. Also provided are methods of making and using the chimeric cytokine receptors described herein.