Allogene Therapeutics, Inc.
IMPROVED T CELL COMPOSITIONS AND METHODS
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Abstract:
The present invention provides compositions and methods that downregulate major histocompatibility class I molecule cell surface expression, and uses of such compositions and methods for improving the functional activities of isolated T cells (e.g., gene-modified antigen-specific T cells, such as chimeric antigen receptor T (CAR-T) cells). In particular, the present invention provides methods and compositions for bolstering the therapeutic efficacy of CAR-T cells.
Status:
Application
Type:
Utility
Filling date:
18 Apr 2018
Issue date:
24 Dec 2020