Allogene Therapeutics, Inc.
METHODS FOR ENHANCING TCRab+ CELL DEPLETION

Abstract:

Provided herein are improved methods for robust TCR+ cell depletion and production of populations of TCR- cells, which can be beneficial to minimize the GvHD risk in patients receiving allogeneic CAR T cell therapy. Provided herein are methods that increase the efficiency of depleting TCR+ cells from a population of cells in order to significantly reduce any residual levels of TCR+ cells present in cell populations in which expression of endogenous TCR has been reduced or eliminated. Associated kits and cell populations are also provided.