Allogene Therapeutics, Inc.
CHIMERIC CYTOKINE RECEPTORS BEARING A PD-1 ECTODOMAIN
Last updated:
Abstract:
Provided herein are PD-1 chimeric cytokine receptors. When present on chimeric antigen receptor (CAR)-bearing immune cells, such receptors allow for increased immune cell activation, proliferation, persistence, and/or potency, when engaged with PD-1 ligands or activation with an anti-PD-1 antibody. Also provided are methods of making and using the chimeric cytokine receptors described herein.
Status:
Application
Type:
Utility
Filling date:
28 Feb 2020
Issue date:
3 Sep 2020