Allogene Therapeutics, Inc.
CHIMERIC CYTOKINE RECEPTORS BEARING A PD-1 ECTODOMAIN

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Abstract:

Provided herein are PD-1 chimeric cytokine receptors. When present on chimeric antigen receptor (CAR)-bearing immune cells, such receptors allow for increased immune cell activation, proliferation, persistence, and/or potency, when engaged with PD-1 ligands or activation with an anti-PD-1 antibody. Also provided are methods of making and using the chimeric cytokine receptors described herein.

Status:
Application
Type:

Utility

Filling date:

28 Feb 2020

Issue date:

3 Sep 2020