Allogene Therapeutics, Inc.
Modified caspase-9 polypeptides and methods of use thereof
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Abstract:
Provided herein are modified caspase-9 polypeptides, and chimeric caspase-9 proteins containing the modified caspase-9 polypeptides. The disclosure further provides polynucleotides encoding these proteins, engineered host cells containing these polynucleotides and proteins, including host cells that co-express a chimeric antigen receptor, and methods of making and using the same.
Status:
Grant
Type:
Utility
Filling date:
31 Oct 2018
Issue date:
10 May 2022