Allogene Therapeutics, Inc.
Inhibitory chimeric antigen receptors

Abstract:

The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and, an intracellular domain wherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein said ITSM is a sequence of amino acid TX.sub.1YX.sub.2X.sub.3X.sub.4, wherein X.sub.1 is an amino acid X.sub.2 is an amino acid X.sub.3 is an amino acid and X.sub.4 is V or I.