Alexion Pharmaceuticals, Inc.
ALKALINE PHOSPHATASE POLYPEPTIDES AND METHODS OF USE THEREOF

Abstract:

Featured are pharmaceutical compositions that include a soluble alkaline phosphatase for treating bone mineralization disorders, such as hypophosphatasia (HPP), and symptoms thereof. The polypeptides include a soluble alkaline phosphatase (sALP) or fragment thereof, which is derived from a naturally occurring alkaline phosphatase (ALP).