Amgen Inc.
Decreasing ornithine production to decrease high mannose glycoform content of recombinant proteins
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Abstract:
The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.
Status:
Grant
Type:
Utility
Filling date:
9 Dec 2014
Issue date:
24 Dec 2019