Amgen Inc.
Bicyclic ketone sulfonamide compounds

Abstract:

The present invention provides compounds of Formula (I), ##STR00001## wherein: ##STR00002## as defined in the specification, an enantiomer, diastereomer, atropisomer thereof, or a mixture thereof, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.