Amgen Inc.
RNAi Constructs for Inhibiting ASGR1 Expression and Methods of Use Thereof

Abstract:

The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.