Amgen Inc.
METHODS FOR INCREASING MANNOSE CONTENT OF RECOMBINANT PROTEINS
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Abstract:
The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
Status:
Application
Type:
Utility
Filling date:
9 Aug 2019
Issue date:
28 Nov 2019