Amgen Inc.
Variants of tissue inhibitor or metalloprotienase type three (TIMP-3), compositions and methods

Abstract:

The application concerns tissue inhibitor of metalloproteinase 3 (TIMP-3) muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them; in particular, muteins of TIMP-3 with specific amino acid substitutions in order to introduce N-linked glycosylation sites.