Amgen Inc.
CYCLOBUTYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS

Abstract:

The present invention provides a cyclobutyl dihydroquinoline sulfonamide compound of Formula (I), ##STR00001## an enantiomer, diastereoisomer, atropisomer thereof, a mixture thereof, or a pharmaceutically acceptable salt thereof, that inhibits voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders, cough, and itch. Also provided are pharmaceutical compositions containing the compounds of the present invention. Also further provided is an atropi-selective preparation of said compounds of Formula (I), and intermediate thereof.