Amgen Inc.
Methods of treatment using an interferon gamma inhibitor

Abstract:

The invention encompasses methods of treatment of interferon gamma (IFN-.gamma.)-mediated diseases using IFN-.gamma. inhibitors, such as anti-huIFN-.gamma. antibodies, wherein levels of expression of one or more biomarkers are determined either before administration of the IFN-.gamma. inhibitor and/or after administration. Also contemplated are methods of treatment using particular, pharmacodynamically effective doses of an anti-huIFN-.gamma. antibody.