Amgen Inc.
Antigen binding proteins that bind to a complex comprising .beta.-Klotho and an FGF receptor

Abstract:

The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing .beta.-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising .beta.-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c.