Amgen Inc.
RNAi CONSTRUCTS AND METHODS FOR INHIBITING MARC1 EXPRESSION

Abstract:

The present invention relates to RNAi constructs for reducing expression of the MARC1 gene. Methods of using such RNAi constructs to treat or prevent liver fibrosis and fatty liver diseases, such as nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, are also described.