Amgen Inc.
Direct selection of cells expressing high levels of heteromeric proteins using glutamine synthetase intragenic complementation vectors

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Abstract:

This invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns improved selection of cells transfected with recombinantly engineered vectors designed to express polypeptides, in particular heteromultimeric polypeptides.

Status:
Grant
Type:

Utility

Filling date:

11 May 2017

Issue date:

12 Jul 2022