Amgen Inc.
Methods for increasing mannose content of recombinant proteins
Last updated:
Abstract:
The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.
Status:
Grant
Type:
Utility
Filling date:
22 Nov 2021
Issue date:
6 Sep 2022