Amgen Inc.
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR

Last updated:

Abstract:

The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsu- lfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.

Status:
Application
Type:

Utility

Filling date:

13 Oct 2021

Issue date:

8 Sep 2022