Amyris, Inc.
COMPOSITIONS AND METHODS FOR PRODUCTION OF MYRCENE
Last updated:
Abstract:
Provided herein are compositions and methods for producing myrcene by culturing genetically modified microbial host cells that express a myrcene synthase and optionally a geranyl pyroplosphate synthase. Also provided herein are isolated nucleic acid molecules that encode myrcene synthase variants derived from the Ocimum species myrcene synthase, which comprise one or more amino acid substitutions that improve in vivo performance of myrcene synthase in genetically modified microbial host cells. Also provided herein are isolated myrcene synthase variants that exhibit an improved activity for converting geranyl diphosphate into myrcene.
Status:
Application
Type:
Utility
Filling date:
9 Jul 2021
Issue date:
6 Jan 2022