AnaptysBio, Inc.
Method of treating pustular psoriasis with antibodies directed against interleukin 36 receptor (IL-36R)

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Abstract:

The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the interleukin 36 receptor (IL-36R). The invention provides an IL-36R-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-36R-binding agent to treat a disorder or disease that is responsive to IL-36R inhibition, such as cancer, an infectious disease, or an autoimmune disease.

Status:
Grant
Type:

Utility

Filling date:

18 Nov 2019

Issue date:

28 Sep 2021