Apellis Pharmaceuticals, Inc.
TREATMENT OF DISORDERS

Abstract:

In some aspects, the disclosure provides methods of treating a subject in need of treatment for a chronic inflammatory disorder or autoimmune disorder. In some embodiments provided methods comprise administering an iC3b/C3dg/C3d inhibitor to the subject. In some embodiments the methods comprise administering an iC3b/C3dg/C3d inhibitor and/or a complement inhibitor to the subject, so that the subject is exposed to both. For example, in some embodiments, provided methods may comprise administering a complement inhibitor to a subject who has received one or more doses of an iC3b/C3dg/C3d inhibitor, or may comprise administering an iC3b/C3dg/C3d inhibitor to a subject who has received one or more doses of a complement inhibitor. Also provided are methods of identifying candidate agents for treatment of chronic inflammatory or autoimmune disorders, and/or of characterizing agents for use in such treatment.