Aptose Biosciences Inc.
FUSED PYRIMIDINE COMPOUNDS AS BRD4 AND JAK2 DUAL INHIBITORS AND METHODS FOR USE THEREOF

Abstract:

The present invention relates to fused pyrimidine compounds, particularly pyrrolopyrimidine and thienopyrimidine compounds and derivatives thereof, pharmaceutical compositions thereof, and methods of inhibiting BRD4 and/or JAK2, as well as methods of treating various diseases and conditions, such as cancer and leukemia, with such compounds. Bromodomain binding and JAK activity are included.